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- Ewing’s Sarcoma/Primitive Neuroectodermal Tumor of the Uterine Corpus
- Eung-Seok Lee, Won Hwangbo, Insun Kim
- J Pathol Transl Med. 2015;49(1):66-70. Published online January 15, 2015
- DOI: https://doi.org/10.4132/jptm.2014.10.14
- 10,515 View
- 87 Download
- 3 Web of Science
- 4 Crossref
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Citations
Citations to this article as recorded by
- Primary uterine Ewing sarcoma – A case report
Yen-Chen Wu, Yu-Chien Kao, Ching-Wen Chang
Taiwanese Journal of Obstetrics and Gynecology.2021; 60(1): 142. CrossRef - Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review
Munetoshi Akazawa, Toshiaki Saito, Kazuya Ariyoshi, Masao Okadome, Ryohei Yokoyama, Kenichi Taguchi
Journal of Obstetrics and Gynaecology Research.2018; 44(10): 2008. CrossRef - Clinicopathologic Features of the Non-CNS Primary Ewing Sarcoma Family of Tumors in the Head and Neck Region
Chang Gok Woo, Bora Lee, Joon Seon Song, Kyung-Ja Cho
Applied Immunohistochemistry & Molecular Morphology.2018; 26(9): 632. CrossRef - Primitive neuroectodermal tumor of uterus with synchronous in situ squamous cell carcinoma of cervix–A rare tumor with unusual association
Ramneet Kaur, Shashi Dhawan, Prem Chopra, Sunita Bhalla
Current Medicine Research and Practice.2017; 7(3): 109. CrossRef
- Primary uterine Ewing sarcoma – A case report
- Myxoid Solitary Fibrous Tumor of the Central Nervous System
- Haeri Han, Sangjeong Ahn, Won Hwangbo, Yang Seok Chae
- Korean J Pathol. 2013;47(6):505-506. Published online December 24, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.505
- 5,573 View
- 37 Download
- 1 Crossref
- Myxoid Liposarcoma with Cartilaginous Differentiation: A Case Study with Cytogenetical Analysis
- Hyunchul Kim, Won Hwangbo, Sangjeong Ahn, Suhjin Kim, Insun Kim, Chul Hwan Kim
- Korean J Pathol. 2013;47(3):284-288. Published online June 25, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.284
- 7,071 View
- 40 Download
- 3 Crossref
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Abstract
PDF Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the
CHOP andTLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type IITLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.-
Citations
Citations to this article as recorded by- Myxoid liposarcoma with nuclear pleomorphism: a clinicopathological and molecular study
Naoki Kojima, Takashi Kubo, Taisuke Mori, Kaishi Satomi, Yuko Matsushita, Shintaro Iwata, Yasushi Yatabe, Koichi Ichimura, Akira Kawai, Hitoshi Ichikawa, Akihiko Yoshida
Virchows Archiv.2024; 484(1): 71. CrossRef - The Conundrum of Dedifferentiation in a Liposarcoma at a Peculiar Location: A Case Report and Literature Review
Ana-Maria Ciongariu, Adrian-Vasile Dumitru, Cătălin Cîrstoiu, Bogdan Crețu, Maria Sajin, Dana-Antonia Țăpoi, Aminia-Diana Ciobănoiu, Adrian Bejenariu, Andrei Marin, Mariana Costache
Medicina.2023; 59(5): 967. CrossRef - Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement
Kayo Suzuki, Taketoshi Yasuda, Kenta Watanabe, Takeshi Hori, Masahiko Kanamori, Tomoatsu Kimura
Oncology Letters.2017;[Epub] CrossRef
- Myxoid liposarcoma with nuclear pleomorphism: a clinicopathological and molecular study
- Naked Cuticle Drosophila 1 Expression in Histologic Subtypes of Small Adenocarcinoma of the Lung
- Sangjeong Ahn, Won Hwangbo, Hyunchul Kim, Chul Hwan Kim
- Korean J Pathol. 2013;47(3):211-218. Published online June 25, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.211
- 6,066 View
- 27 Download
- 12 Crossref
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Abstract
PDF
Background Naked cuticle Drosophila 1 (NKD1) has been related to non-small cell lung cancer in that decreased NKD1 levels have been associated with both poor prognosis and increased invasive quality.
Methods Forty cases of lung adenocarcinoma staged as Tis or T1a were selected. Cases were subclassified into adenocarcinoma
in situ (AIS), minimally invasive adenocarcinoma (MIA), and small adenocarcinoma (SAD). Immunohistochemical studies for NKD1 were performed.Results Forty samples comprised five cases of AIS (12.5%), eight of MIA (20.0%), and 27 of SAD (67.5%). AIS and MIA showed no lymph node metastasis and 100% disease-free survival, whereas among 27 patients with SAD, 2 (7.4%) had lymph node metastasis, and 3 (11.1%) died from the disease. Among the 40 cases, NKD1-reduced expression was detected in 8 (20%) samples, whereas normal expression was found in 15 (37.5%) and overexpression in 17 (42.5%). Loss of NKD1 expression was significantly associated with lymph node metastasis (p=0.001). All cases with predominant papillary pattern showed overexpression of NKD1 (p=0.026).
Conclusions Among MIA and SAD, MIA had better outcomes than SAD. Down-regulated NKD1 expression was closely associated with nodal metastasis, and overexpression was associated with papillary predominant adenocarcinoma.
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Citations
Citations to this article as recorded by- Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma
Yu‐Ting Wang, Il‐Chi Chang, Chih‐Yi Chen, Jiun‐Yi Hsia, Frank Cheau‐Feng Lin, Wan‐Ru Chao, Tuan‐Ying Ke, Ya‐Ting Chen, Chih‐Jung Chen, Min‐Shu Hsieh, Shiu‐Feng Huang
Thoracic Cancer.2023; 14(6): 592. CrossRef - Clinical Significance of NKD Inhibitor of WNT Signaling Pathway 1 (NKD1) in Glioblastoma
Lijun Li, Ruiying Gao, Weizhong Huangfu, Fang Zhang, Ruixia Wang, Hongda Liu
Genetics Research.2023; 2023: 1. CrossRef - Naked cuticle homolog 1 prevents mouse pulmonary arterial hypertension via inhibition of Wnt/β-catenin and oxidative stress
Shanwu Wei, Lu Lin, Wen Jiang, Jie Chen, Gu Gong, Daming Sui
Aging.2023;[Epub] CrossRef - MicroRNA‐195‐5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1
Qiang Qu, Xiangdong Chu, Peng Wang
Cell Biology International.2017; 41(3): 287. CrossRef - Downregulation of NKD1 in human osteosarcoma and its clinical significance
Xiang Chen, Ping Xu, Jianwei Zhu, Fan Liu
Molecular Medicine Reports.2017;[Epub] CrossRef - Lung Adenocarcinoma Staging Using the 2011 IASLC/ATS/ERS Classification: A Pooled Analysis of Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma
Madhusmita Behera, Taofeek K. Owonikoko, Anthony A. Gal, Conor E. Steuer, Sungjin Kim, Rathi N. Pillai, Fadlo R. Khuri, Suresh S. Ramalingam, Gabriel L. Sica
Clinical Lung Cancer.2016; 17(5): e57. CrossRef - The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells
Jie Li, Sheng Zhang, Qing Hu, Kang Zhang, Jianbin Jin, Xuqing Zheng, Zhenyu Yin, Xiaomin Wang
Scientific Reports.2016;[Epub] CrossRef - NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma
Sheng Zhang, Jie Li, Xiaomin Wang
Tumor Biology.2016; 37(10): 14059. CrossRef - Expression pattern and clinicopathologic significance of NKD1 in human primary hepatocellular carcinoma
Sheng Zhang, Jie Li, Zhen‐Yu Yin, Ping‐Guo Liu, Wen‐Xiu Zhao, Cheng‐Rong Xie, Bi‐Xin Zhao, Xiao‐Min Wang
APMIS.2015; 123(4): 315. CrossRef - Early lung cancer with lepidic pattern
Wilko Weichert, Arne Warth
Current Opinion in Pulmonary Medicine.2014; 20(4): 309. CrossRef - Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors
Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh
Korean Journal of Pathology.2014; 48(1): 17. CrossRef - The New 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Resected Specimens: Clinicopathologic Relevance and Emerging Issues
Seung Yeon Ha, Mee Sook Roh
Korean Journal of Pathology.2013; 47(4): 316. CrossRef
- Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma
EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast- Won Hwangbo, Jeong Hyeon Lee, Sangjeong Ahn, Seojin Kim, Kyong Hwa Park, Chul Hwan Kim, Insun Kim
- Korean J Pathol. 2013;47(2):107-115. Published online April 24, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.107
- 11,183 View
- 66 Download
- 14 Crossref
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Abstract
PDF
Background The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer treatment.
Methods A total of 706 invasive ductal carcinomas (IDC) of the breast were immunophenotyped, and 82 cases with EGFR protein expression were studied for
EGFR gene amplification.Results EGFR protein was expressed in 121 of 706 IDCs (17.1%); 5.9% were of luminal type, 25.3% of epidermal growth factor receptor 2 (HER-2) type, and 79.3% of basal-like tumors.
EGFR gene amplification and high polysomy (fluorescentin situ hybridization [FISH]-positive) were found in 18 of 82 cases (22.0%); 41.2% of the HER-2+, EGFR+, cytokeratin 5/6- (CK5/6-) group, 11.2% of the HER-2-, EGFR+, CK5/6- group, and 19.1% of the HER-2-, EGFR+, CK5/6+ group. FISH-positive cases were detected in 8.3% of the EGFR protein 1+ expression cases, 15.9% of 2+ expression cases, and 38.5% of 3+ expression cases. In group 2, the tumors had a high Ki-67 labeling (>60%), but the patients showed better disease-free survival than those with tumors that co-expressed HER-2 or CK5/6.Conclusions EGFR-directed therapy can be considered in breast cancer patients with EGFR protein overexpression and gene amplification, and its therapeutic implication should be determined in HER-2 type breast cancer patients.
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Citations
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Cellular Signalling.2021; 79: 109885. CrossRef - Blocking c-MET/ERBB1 Axis Prevents Brain Metastasis in ERBB2+ Breast Cancer
Shailendra K. Gautam, Ranjana K. Kanchan, Jawed A. Siddiqui, Shailendra K. Maurya, Sanchita Rauth, Naveenkumar Perumal, Pranita Atri, Ramakanth C. Venkata, Kavita Mallya, Sameer Mirza, Moorthy P. Ponnusamy, Vimla Band, Sidharth Mahapatra, Maneesh Jain, Su
Cancers.2020; 12(10): 2838. CrossRef - Evaluation of lapatinib cytotoxicity and genotoxicity on MDA-MB-231 breast cancer cell line
Mona A.M. Abo-Zeid, Mahmoud T. Abo-Elfadl, Amira M. Gamal-Eldeen
Environmental Toxicology and Pharmacology.2019; 71: 103207. CrossRef - Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
Jiasheng Xu, Jingjing Guo, Yangkai Jiang, Yujun Liu, Kaili Liao, Zhonghua Fu, Zhenfang Xiong
Cancer Medicine.2019; 8(10): 4722. CrossRef - Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome
Ge Yan, Mohamed E.M. Saeed, Sebastian Foersch, Jose Schneider, Wilfried Roth, Thomas Efferth
Oncotarget.2019; 10(20): 1918. CrossRef - A novel matrine derivative WM622 inhibits hepatocellular carcinoma by inhibiting PI3K/AKT signaling pathways
Xiao Sun, Xiao-bin Zhuo, Yi-ping Hu, Xuan Zheng, Qing-jie Zhao
Molecular and Cellular Biochemistry.2018; 449(1-2): 47. CrossRef - lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR/PI3K/AKT pathway
Yan Zhang, Cheng Xiang, Yuling Wang, Yuanyuan Duan, Ci Liu, Yongli Jin, Yajing Zhang
Biomedicine & Pharmacotherapy.2017; 94: 644. CrossRef - Copy Number Profiling of MammaPrint™ Genes Reveals Association with the Prognosis of Breast Cancer Patients
Areej Fatima, Fomaz Tariq, Muhammad Faraz Arshad Malik, Muhammad Qasim, Farhan Haq
Journal of Breast Cancer.2017; 20(3): 246. CrossRef - Evaluation of serum epidermal growth factor receptor (EGFR) in correlation to circulating tumor cells in patients with metastatic breast cancer
Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter A. Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm, Volkmar Müller
Scientific Reports.2017;[Epub] CrossRef - EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib
James P. De Andrade, Jung M. Park, Vivian W. Gu, George W. Woodfield, Mikhail V. Kulak, Allison W. Lorenzen, Vincent T. Wu, Sarah E. Van Dorin, Philip M. Spanheimer, Ronald J. Weigel
Molecular Cancer Therapeutics.2016; 15(3): 503. CrossRef - Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer
H J Lee, A N Seo, E J Kim, M H Jang, Y J Kim, J H Kim, S-W Kim, H S Ryu, I A Park, S-A Im, G Gong, K H Jung, H J Kim, S Y Park
British Journal of Cancer.2015; 112(1): 103. CrossRef - Epidermal growth factor receptor protein overexpression and gene amplification are associated with aggressive biological behaviors of esophageal squamous cell carcinoma
GANG LIN, XIAO-JIANG SUN, QIAN-BO HAN, ZHUN WANG, YA-PING XU, JIA-LEI GU, WEI WU, GU ZHANG, JIN-LIN HU, WEN-YONG SUN, WEI-MIN MAO
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- Identification of a cross-talk between EGFR and Wnt/beta-catenin signaling pathways in HepG2 liver cancer cells
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